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KMID : 0613820140240091019
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Journal of Life Science
2014 Volume.24 No. 9 p.1019 ~ p.1024
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Effect of Cymbidium Root Extracts on Oxidative Stress-induced Myoblasts Damage
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Kim Wan-Joong
Kim Han-Sung
Opitz Joerg
Kabayama Kazuya
Kim Tack-Joong
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Abstract
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Skeletal muscle atrophy can be defined as a decrease in or a disease of the muscle tissue, or as a disorder of the nerves that control the muscle, through injury or lack of use. This condition is associated with reactive oxygen species (ROS), resulting in various muscular disorders. Exposure to ROS induces muscle atrophy through several biological factors, such as SOD1 and HSP70. We found that cymbidium root extract reduced the H2O2-induced viability loss in C2C12 myoblasts and inhibited apoptosis. In addition, we showed that the cymbidium root extract increased the expression of HSP70 and decreased the expression of SOD1 in the H2O2-induced C2C12 myoblasts. These results suggest that cymbidium root extract might have therapeutic value in reducing ROS-induced muscle atrophy.
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KEYWORD
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Cymbidium, heat shock protein 70, reactive oxygen species
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